Biointerfaces Institute

Redefining collaboration in the physical and life sciences

Contact Us: 734.763.7924
Email: Biointerfaces.Info@umich.edu

People

Steven Schwendeman

Ara G. Paul Professor and Chair, Department of Pharmaceutical Sciences Biointerfaces Institute - Executive Committee

Biomaterials & Drug Delivery

The Schwendeman Group develops advanced polymer-based controlled drug delivery approaches, including: physical chemistry of poly(lactic-co-glycolic acid) (PLGA) and related polymers; aqueous-based encapsulation of biomacromolecules in PLGAs, mechanisms of polymer healing and drug-polymer interactions; mechanisms of instability of small and large molecules in PLGAs particularly proteins and peptides; vaccine delivery from PLGAs; PLGA nanoparticle formulation; and development of mucoadhesive polymers/formulations for intraoral and intranasal delivery.  These drug delivery strategies are most often applied to important therapeutic targets, e.g., angiogenesis in cardiovascular disease, anti-angiogenesis for macular degeneration, bone regeneration, anti-cancer therapies, and diabetes. 

Schwendeman Lab

 

 

Anna Schwendeman

Assistant Professor, Pharmaceutical Sciences, College of Pharmacy

Nanotechnology

Schwenedeman's principal research interest is to understand how phospholipid composition of high-density lipoprotein (HDL) affects its potency and to design short synthetic peptides that mimic various functions of Apolipoprotein A-I, the main HDL protein. Laboratory work focuses on HDL for treatment of sepsis, Alzheimer's disease, complications of diabetes, lupus and other autoimmune diseases and using synthetic HDL nanoparticles for targeted drug delivery purposes and designing artificial HDL based on gold nanoparticles. Long-term research goal includes the design of highly potent synthetic HDL nanoparticles to treat atherosclerosis.

Schwendeman Lab

 

 

Lonnie Shea

William and Valerie Hall Chair, Biomedical Engineering; Professor, Biomedical Engineering

Cell & Tissue Engineering

Shea Lab

 

 

Diane Simeone

Lazar J Greenfield Professor, Surgery; Professor, Surgery; Professor, Molecular and Integrative Physiology; Associate Chair of Research, and Director of Translational Research, Medical School

Cell & Tissue Engineering

 

 

Mike Solomon

Professor, Chemical Engineering & Macromolecular Science and Engineering Associate Dean for Academic Programs and Initiatives, Rackham Graduate School

Nanotechnology

Solomon Group research interests are in the area of soft matter - materials with properties intermediate between fluids and solids. The Solomon group has developed and applied 3D confocal microscopy, rheological, and light scattering methods to study the soft matter phenomena of self-assembly, gelation, and the biomechanics of bacterial biofilms.

Solomon Lab

 

 

William Stacey

Associate Professor, Neurology and Biomedical Engineering

Microfluidics & Sensors

Dr. Stacey’s lab is dedicated to developing better implantable devices to control epilepsy.

Stacey Lab

 

 

Shuichi Takayama

Professor, Biomedical Engineering and Macromolecular Science and Engineering Biointerfaces Institute – Executive Committee

Microfluidics & Sensors

Current research interests of the Takayama Group include: micro/nanofluidics, cellular microenvironment engineering, epigenetics, and protein biomarker analysis. Technologically, the group works on microfluidics, aqueous two phase systems, self-switching fluidic circuits, and nanofluidics that are used to construct microfluidic models of the body such as artificial oviducts for enhanced in vitro fertilization treatment, microtissue engineered models of lung injury, and 3D models of cancer metastasis for drug testing. Work also includes multiplexed immunoassays, multi-color histone modification mapping from single chromatin strands, and studying timing and rhythms of cell signaling.

Takayama Lab

 

 

Peter Tessier

Albert M. Mattocks Professor of Pharmaceutical Sciences and Chemical Engineering

Biomaterials & Drug Delivery

The Tessier lab aims to develop next generation technologies for designing, discovering, engineering, characterizing, formulating and delivering biologics ranging from small affinity peptides to large monoclonal antibodies for molecular imaging, diagnostic and therapeutic applications.

Tessier Lab

 

 

Anish Tuteja

Associate Professor, Materials Science and Engineering

Biomaterials & Drug Delivery

The Tuteja Group research interests are in the area of surface science. Specifically, the Group works on developing so called super-omniphobic surfaces (surfaces on which all liquids bead up and roll-off). They have also developed a novel technique to fabricate, on a very large scale, nano- and micro- particles of any size, shape, or chemistry. The developed particles shape, size and composition can be used to engineer bio-distribution, skin or lung uptake, intra-cellular localization and cell response. This technique can also be used to fabricate mono-, bi- (or Janus), tri- and multi-phasic polymeric particles with any desired composition.

Tuteja Group

 

 

Scott VanEpps

Assistant Professor, Emergency Medicine

Biomaterials & Drug Delivery

Dr. VanEpps research currently focuses on the prevention and treatment of medical device related infection.

Van Epps

 

 

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