Dr. Jack Parent is a Professor of Neurology, Director of the Neurodevelopment and Regeneration Laboratory and Co-director of the Comprehensive Epilepsy Center. Reprogramming somatic cells to a pluripotent state via the induced pluripotent stem cell (iPSC) method offers an unparalleled approach for neurological disease modeling using patient-derived cells. I describe our application of the iPSC approach to model severe pediatric genetic epilepsies with patient-derived cells. Our 2-D iPSC culture studies of SCN1A-linked Dravet Syndrome show altered sodium currents and excitability…