Single Cell Technologies
This cluster focuses on the development of methods and technologies to probe a single cell.
This goal of this cluster is to build a synergistic scientific and technological platform to investigate one of the most critical building blocks of any biological system – a cell. Through the convergence of biology, computational approaches and engineering, the cluster addresses fundamental biological questions on cellular heterogeneity by developing integrated approaches and technologies to isolate, preserve, characterize and expand rare cells. This approach will enable investigation of basic biological components of single cells at a higher resolution and holds the promise of transforming the study, diagnosis and treatment of every disease. The cluster builds upon an existing ecosystem of UM investigators with complementary research excellence and active collaborations from engineering, physical sciences, life sciences and the medical school.
Recent Publications![Three-dimensional (3D) adipose tissue organoids for disease modeling. Lipid (red), actin (green), nucleus (blue).](https://biointerfaces.umich.edu/wp-content/uploads/2017/11/3D-adipose.jpg)
Three-dimensional (3D) adipose tissue organoids for disease modeling. Lipid (red), actin (green), nucleus (blue).
![Cell in an engineered scaffold](https://biointerfaces.umich.edu/wp-content/uploads/2017/11/scaffold.jpg)
Cell in an engineered scaffold
Related Press Releases & Articles
![Default Featured Image](https://biointerfaces.umich.edu/wp-content/uploads/2017/12/default-featured-image-02-1920x1280.jpg)
- May 17, 2021 / Award
2021 BI Innovator Awardees
Congratulations to the 2021 BI Innovator Award Recipients. BI Innovator awards recognize members of the BI research community who are active participants in the research, innovation and translational ecosystem at BI and making a difference in our community.
![Female scientist with PPE holding a red transparent pill](https://biointerfaces.umich.edu/wp-content/uploads/2021/04/AdobeStock_170028754-1920x1280.jpeg)
- April 1, 2021 / Article
Recent BI Publications
Publications from BI Research Groups in March
![Biointerfaces Background 03](https://biointerfaces.umich.edu/wp-content/uploads/2017/12/bio-bg-03-1920x1280.jpg)
- March 30, 2021 @ 3:30 pm
BI Distinguished Lectureship Series with Dr. James Kirkland
Join us on March 30 for a Distinguished Lecture by Dr. James Kirkland from @MayoClinic on his research on aging, cellular senescence and age-related diseases.
- March 17, 2021 / Article
Kotov Lab develops structural batteries for mobile robots
Researchers in the Kotov lab are working on biomorphic structural batteries which could provide more energy to robots.
![Culturing cells in tissue culture plates](https://biointerfaces.umich.edu/wp-content/uploads/2021/03/AdobeStock_102697862-1920x1280.jpeg)
- March 1, 2021 / Article
Recent BI Publications
Publications from BI Research Groups in February
![Microscope with laboratory glassware, generic image](https://biointerfaces.umich.edu/wp-content/uploads/2021/02/AdobeStock_197157339-1920x1280.jpeg)
- February 1, 2021 / Article
Recent BI Publications
Publications from BI Research Groups in January
![Three women working in a fume hood in a lab.](https://biointerfaces.umich.edu/wp-content/uploads/2017/12/sunitha-nagrath-cell-tissue-1920x1280.jpg)
- January 29, 2021 / Article
S. Nagrath Lab develops new microfluidic chip to capture and investigate exosomes
The Sunitha Nagrath lab reports on their work to capture natural killer cells and harvest exosomes to investigate their potential for battling cancer cells.
![beaker and flask glass in chemistry blue science laboratory background](https://biointerfaces.umich.edu/wp-content/uploads/2020/12/AdobeStock_315669632-1920x1280.jpeg)
- December 1, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in November
![running a blood sample through a](https://biointerfaces.umich.edu/wp-content/uploads/2020/10/che_nagrath_labyrinthchip_jx005_36923349795_o-1920x1280.jpg)
- October 30, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in October
![Nicholas Kotov](https://biointerfaces.umich.edu/wp-content/uploads/2020/10/20160404_kotovawardportraits_jx002_25966224270_o-1920x1280.jpg)
- October 12, 2020 / Award
Kotov Recipient of Alpha Chi Sigma Award
For his work in self-assembly processes at the nanoscale, Nick Kotov received the 2020 Alpha Chi Sigma Award.
![Header: Phd Defense](https://biointerfaces.umich.edu/wp-content/uploads/2023/02/01a_MEP-F-Postcard-4x6-1-4-1920x1280.jpg)
- February 20, 2023 @ 10:00 am
PhD Defense- Jacqueline Larouche
Title: Understanding and Rewriting Cellular and Molecular Programs to Restore Skeletal Muscle Homeostasis
Chair: Carlos Aguilar
![Nicholas Kotov shows one of the original paper models that served for inspiration for a stretchable conductor made out of mesh structure of carbon nanotubes](https://biointerfaces.umich.edu/wp-content/uploads/2022/06/20150601_kirigami_jx013_18391608965_o-1920x1280.jpg)
- November 30, 2022 / Article
‘Transformer’ pinwheels offer twist on nano-engineered materials
A newly discovered pinwheel structure — self-assembled from pyramid-shaped nanoparticles — may enable unique material properties that could be useful in areas like machine vision, armor, chemical and biological sensing, and more.
![Scientists working in a lab](https://biointerfaces.umich.edu/wp-content/uploads/2022/10/09142022_ovarian-cancer-research_nagrath-1920x1280.jpg)
- October 7, 2022 / Press Release
Shutting down backup genes leads to cancer remission in mice
Cancer cells delete DNA when they go to the dark side, so a team of doctors and engineers – led by Deepak Nagrath – targeted the ‘backup plans’ running critical cell functions
![A presentation being given to a room full of people](https://biointerfaces.umich.edu/wp-content/uploads/2022/08/20220423_095153-1920x1280.jpg)
- August 12, 2022 / Press Release
Neuroregeneration and Cognition Challenge Seed Fund Awards
We are pleased to announce the funding selections for the MNI-BI 2022 Neuroregeneration and Cognition Challenge seed fund competition.
![Default Featured Image](https://biointerfaces.umich.edu/wp-content/uploads/2017/12/default-featured-image-02-1920x1280.jpg)
- August 4, 2022 / Award
2022 BI Innovator Awards
Congratulations to the 2022 BI Innovator Award Recipients. BI Innovator awards recognize members of the BI research community who are active participants in the research, innovation and translational ecosystem at BI and making a difference in our community.
![NCRC Building](https://biointerfaces.umich.edu/wp-content/uploads/2022/08/NCRC-Michigan-Engineering-Flickr-7550679828_c3224460cc_o-1920x1280.jpg)
- August 1, 2022 / Press Release
New members join BI’s External Advisory Board
BI welcomes Carl Gordon and Natasha Shervani of OrbiMed as new members of its External Advisory Board.
![Nicholas Kotov and Scott VanEpps discussing.](https://biointerfaces.umich.edu/wp-content/uploads/2022/05/picture-2-1920x1280.jpg)
- May 19, 2022 / Article
Nanobiotics: Model predicts how nanoparticles interact with proteins
Developed in the VanEpps and Kotov labs, a new machine learning model that predicts interactions between nanoparticles and proteins.
![Default Featured Image](https://biointerfaces.umich.edu/wp-content/uploads/2017/12/default-featured-image-02-1920x1280.jpg)
- October 7, 2021 @ 9:00 am
BI Distinguished Lectureship Series with Dr. John S. Condeelis
Join us on October 7for a Distinguished Lecture by Dr. John S. Condeelis
![Carlos Aguilar](https://biointerfaces.umich.edu/wp-content/uploads/2017/11/Carlos-Aguilar-1920x1280.jpg)
- August 3, 2021 / Award
Carlos Aguilar receives NSF CAREER Award
The project is entitled “CAREER: Understanding the Interdependence of the Microenvironment and Nuclear Organization in Stem Cell Aging.”
![Blue cell representing immune cell interacting with red cell representing cancer cell](https://biointerfaces.umich.edu/wp-content/uploads/2021/05/bibc-cover-1-1920x1280.jpg)
- July 22, 2021 / Press Release
BioInnovations in Brain Cancer launches faculty search
The BioInnovations in Brain Cancer Initiative (BIBC) at the University of Michigan invites applications for a tenure-track position at any level in brain cancer biology and technology research (including, drug/molecular transport/imaging in the brain tissue; translation-focused glioma, epigenetics and/or scRNA-seq research; and non-viral nucleic acid delivery).
Applications will be accepted on a rolling basis, but review of applications will begin on October 1, 2021.
![Default Featured Image](https://biointerfaces.umich.edu/wp-content/uploads/2017/12/default-featured-image-02-1920x1280.jpg)
- May 17, 2021 / Award
2021 BI Innovator Awardees
Congratulations to the 2021 BI Innovator Award Recipients. BI Innovator awards recognize members of the BI research community who are active participants in the research, innovation and translational ecosystem at BI and making a difference in our community.
![Female scientist with PPE holding a red transparent pill](https://biointerfaces.umich.edu/wp-content/uploads/2021/04/AdobeStock_170028754-1920x1280.jpeg)
- April 1, 2021 / Article
Recent BI Publications
Publications from BI Research Groups in March
![Biointerfaces Background 03](https://biointerfaces.umich.edu/wp-content/uploads/2017/12/bio-bg-03-1920x1280.jpg)
- March 30, 2021 @ 3:30 pm
BI Distinguished Lectureship Series with Dr. James Kirkland
Join us on March 30 for a Distinguished Lecture by Dr. James Kirkland from @MayoClinic on his research on aging, cellular senescence and age-related diseases.
- March 17, 2021 / Article
Kotov Lab develops structural batteries for mobile robots
Researchers in the Kotov lab are working on biomorphic structural batteries which could provide more energy to robots.
![Culturing cells in tissue culture plates](https://biointerfaces.umich.edu/wp-content/uploads/2021/03/AdobeStock_102697862-1920x1280.jpeg)
- March 1, 2021 / Article
Recent BI Publications
Publications from BI Research Groups in February
![Microscope with laboratory glassware, generic image](https://biointerfaces.umich.edu/wp-content/uploads/2021/02/AdobeStock_197157339-1920x1280.jpeg)
- February 1, 2021 / Article
Recent BI Publications
Publications from BI Research Groups in January
![Three women working in a fume hood in a lab.](https://biointerfaces.umich.edu/wp-content/uploads/2017/12/sunitha-nagrath-cell-tissue-1920x1280.jpg)
- January 29, 2021 / Article
S. Nagrath Lab develops new microfluidic chip to capture and investigate exosomes
The Sunitha Nagrath lab reports on their work to capture natural killer cells and harvest exosomes to investigate their potential for battling cancer cells.
![beaker and flask glass in chemistry blue science laboratory background](https://biointerfaces.umich.edu/wp-content/uploads/2020/12/AdobeStock_315669632-1920x1280.jpeg)
- December 1, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in November
![running a blood sample through a](https://biointerfaces.umich.edu/wp-content/uploads/2020/10/che_nagrath_labyrinthchip_jx005_36923349795_o-1920x1280.jpg)
- October 30, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in October
![Nicholas Kotov](https://biointerfaces.umich.edu/wp-content/uploads/2020/10/20160404_kotovawardportraits_jx002_25966224270_o-1920x1280.jpg)
- October 12, 2020 / Award
Kotov Recipient of Alpha Chi Sigma Award
For his work in self-assembly processes at the nanoscale, Nick Kotov received the 2020 Alpha Chi Sigma Award.
![Header: Phd Defense](https://biointerfaces.umich.edu/wp-content/uploads/2023/02/01a_MEP-F-Postcard-4x6-1-4-1920x1280.jpg)
- February 20, 2023 @ 10:00 am
PhD Defense- Jacqueline Larouche
Title: Understanding and Rewriting Cellular and Molecular Programs to Restore Skeletal Muscle Homeostasis
Chair: Carlos Aguilar
![Nicholas Kotov shows one of the original paper models that served for inspiration for a stretchable conductor made out of mesh structure of carbon nanotubes](https://biointerfaces.umich.edu/wp-content/uploads/2022/06/20150601_kirigami_jx013_18391608965_o-1920x1280.jpg)
- November 30, 2022 / Article
‘Transformer’ pinwheels offer twist on nano-engineered materials
A newly discovered pinwheel structure — self-assembled from pyramid-shaped nanoparticles — may enable unique material properties that could be useful in areas like machine vision, armor, chemical and biological sensing, and more.
![Scientists working in a lab](https://biointerfaces.umich.edu/wp-content/uploads/2022/10/09142022_ovarian-cancer-research_nagrath-1920x1280.jpg)
- October 7, 2022 / Press Release
Shutting down backup genes leads to cancer remission in mice
Cancer cells delete DNA when they go to the dark side, so a team of doctors and engineers – led by Deepak Nagrath – targeted the ‘backup plans’ running critical cell functions
![A presentation being given to a room full of people](https://biointerfaces.umich.edu/wp-content/uploads/2022/08/20220423_095153-1920x1280.jpg)
- August 12, 2022 / Press Release
Neuroregeneration and Cognition Challenge Seed Fund Awards
We are pleased to announce the funding selections for the MNI-BI 2022 Neuroregeneration and Cognition Challenge seed fund competition.
![Default Featured Image](https://biointerfaces.umich.edu/wp-content/uploads/2017/12/default-featured-image-02-1920x1280.jpg)
- August 4, 2022 / Award
2022 BI Innovator Awards
Congratulations to the 2022 BI Innovator Award Recipients. BI Innovator awards recognize members of the BI research community who are active participants in the research, innovation and translational ecosystem at BI and making a difference in our community.
![NCRC Building](https://biointerfaces.umich.edu/wp-content/uploads/2022/08/NCRC-Michigan-Engineering-Flickr-7550679828_c3224460cc_o-1920x1280.jpg)
- August 1, 2022 / Press Release
New members join BI’s External Advisory Board
BI welcomes Carl Gordon and Natasha Shervani of OrbiMed as new members of its External Advisory Board.
![Nicholas Kotov and Scott VanEpps discussing.](https://biointerfaces.umich.edu/wp-content/uploads/2022/05/picture-2-1920x1280.jpg)
- May 19, 2022 / Article
Nanobiotics: Model predicts how nanoparticles interact with proteins
Developed in the VanEpps and Kotov labs, a new machine learning model that predicts interactions between nanoparticles and proteins.
![Default Featured Image](https://biointerfaces.umich.edu/wp-content/uploads/2017/12/default-featured-image-02-1920x1280.jpg)
- October 7, 2021 @ 9:00 am
BI Distinguished Lectureship Series with Dr. John S. Condeelis
Join us on October 7for a Distinguished Lecture by Dr. John S. Condeelis
![Carlos Aguilar](https://biointerfaces.umich.edu/wp-content/uploads/2017/11/Carlos-Aguilar-1920x1280.jpg)
- August 3, 2021 / Award
Carlos Aguilar receives NSF CAREER Award
The project is entitled “CAREER: Understanding the Interdependence of the Microenvironment and Nuclear Organization in Stem Cell Aging.”
![Blue cell representing immune cell interacting with red cell representing cancer cell](https://biointerfaces.umich.edu/wp-content/uploads/2021/05/bibc-cover-1-1920x1280.jpg)
- July 22, 2021 / Press Release
BioInnovations in Brain Cancer launches faculty search
The BioInnovations in Brain Cancer Initiative (BIBC) at the University of Michigan invites applications for a tenure-track position at any level in brain cancer biology and technology research (including, drug/molecular transport/imaging in the brain tissue; translation-focused glioma, epigenetics and/or scRNA-seq research; and non-viral nucleic acid delivery).
Applications will be accepted on a rolling basis, but review of applications will begin on October 1, 2021.