Cell and Tissue Engineering
Scientists in the Cell and Tissue Engineering Cluster are inspired to better understand fundamental principles of cell biology and exploit this knowledge to regenerate tissues and treat debilitating human diseases.
These efforts are supported by the daily interaction among basic scientists, engineers, and clinicians that creates an environment to innovate and discover. Current lab groups focus in the areas of tissue engineering, the role of tissue remodeling in the progression of metabolic and cardiovascular diseases, and human pluripotent stem cell and cancer stem cell biology.
Tissue engineering projects include design and fabrication of biomaterials as cell, protein or gene delivery devices, genetic engineering to direct cell and protein activity, and the development of multi-tissue interfaces. The metabolic modeling group focuses on the role of extracellular matrix remodeling (ECM) in the regulation of metabolism. By using genetically modified mouse models, three-dimensional (3-D) tissue culture, they work to define the molecular mechanism by which 3-D ECM remodeling regulates transcription, differentiation, and metabolic function in vitro and in vivo. Projects in the pluripotent stem cell group focus on how constituents of cell signaling pathways regulate transcription factors to balance self-renewal and cell differentiation in both human embryonic stem cells and induced pluripotent stem cells. The cancer stem cell group has elucidated a number of intrinsic and extrinsic pathways that regulate self-renewal and cell fate decisions in cancer stem cells and is translating these pre-clinical research findings into the development of clinical trials designed to target breast cancer stem cells.
Related Press Releases & Articles
- April 3, 2018 / Article
Carlos Aguilar wins Non-Tenured Faculty Award from 3M
Carlos Aguilar is one of the recipients of the 2018 3M Non-Tenured Faculty Awards. Awarded by 3M Corporation, this award recognizes junior faculty who demonstrate outstanding research, experience, teaching and academic leadership.
- March 14, 2018 / Press Release
Press Release – 3D Printing for Medicine
A collaborative project from the Lahann, Luker and Krebsbach labs reports on new jet writing technique for printing 3D structures for biomedical applications.
- March 1, 2018 / Article
Interdisciplinary team of BI researchers publish new article on 3-D Jet Writing Technique
The article entitled “3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures” appears in Advanced Materials.
- February 5, 2018 / Award
Two BI research fellows awarded MICHR Award
Patricia Schnepp, PhD and Vishwanath Sankarasubramanian, PhD receive Postdoctoral Translational Scholars Program (PTSP) Awards from MICHR.
- January 30 @ 12:00 pm
Marc Thurner, CEO of RegenHu, will be discussing the company’s line of 3D bioprinters.
- January 23, 2018 / Press Release
Diabetes and Its Complications Challenge Seed Funds Awards
We are pleased to announce our selection for the Diabetes and Its Complications Challenge seed fund competition.
- January 10, 2018 / Press Release
Carlos Aguilar joins BI
Carlos Aguilar, Assistant Professor of Biomedical Engineering, and his research group recently joined BI. The Nano-Omic-Bio-Engineering Lab (NOBEL) is working on developing new approaches and tools to understand and investigate skeletal muscles.
- November 29, 2017 / Press Release
Nanoparticles self-assemble into nanoshells
Research in the Kotov group demonstrated the self-assembly of inorganic nanoparticles into nanoshells, which can potentially be used for gene delivery applications. More details here.
- November 29, 2017 / Featured
Scaffold-Based Lung Organoid
Lonnie Shea’s research group developed scaffold technologies to grow lung organoids.
- September 27, 2017 / Article
Findings on Circulating Tumor Cells published in Cell Systems
A research article from Sunitha Nagrath’s lab, in collaboration with the Keller, Wicha and Simeone groups, entitled “High-Throughput Microfluidic Labyrinth for Label-free Isolation of Circulating Tumor Cells” was published in Cell Systems.
- September 25, 2017 / Press Release
Nagrath identifying new cancer targets
In work started during his time at Rice University, Deepak Nagrath continues to research cancer cell metabolism and how cancer cells interact. Learning how the cells communicate could lead to new targets for more effective treatments than those currently is use.
- September 21, 2017 / Press Release
Labyrinth chip developed by Nagrath and Wicha used in clinical trial
Currently being used in a breast cancer clinical trial to isolate cancer cells in blood, Sunitha Nagrath and Max Wicha led the development of a hydrodynamic maze called the labyrinth chip. With its innovative design, the labyrinth chip allows researchers to capture cells for molecular analysis so they can know what to target with treatments.
- September 12, 2017 / Press Release
Lahann part of newly awarded NSF-ERC center
BI director, Joerg Lahann, is part of the U-M team for the newly announced NSF Engineering Research Center (ERC). Led by Boston University, the NSF-ERC aims to grow new heart tissues. For more details on the award and team, please visit here.
- September 6, 2017 / Article
Joint Moon and A. Schwendeman research on HDL nanodisks
The article entitled “Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma” was published in International Journal of Nanomedicine.
- September 1, 2017 / Article
Deepak Nagrath reports findings on the role of Nitric Oxide in Cancer
“Nitric Oxide: The Forgotten Child of Tumor Metabolism” appears in Trends in Cancer
- August 30, 2017 / Press Release
Blood test being used to predict lung cancer prognosis
The Single Cell Analysis Core, led by co-directors Evan Keller and Sunitha Nagrath, is using blood tests to isolate cancer cells to better understand the disease. In what they hope to become routine practice, “liquid biopsies” are being analyzed to provide an early determination of whether patients may need additional treatment.
- July 5, 2017 / Article
The Shea group investigates antigen-conjugated nanoparticle treatment
The article entitled “Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression of T Cell Activity to Induce Tolerance” was published in Molecular Therapy.
- July 1, 2017 / Article
The Chun Lab reports on the role of MT1-MMP in antherosclerosis
“Membrane-Tethered Metalloproteinase Expressed by Vascular Smooth Muscle Cells Limited the Progression of Proliferative Atherosclerotic Lesions” appears in the Journal of the American Heart Association.
- May 1, 2017 / Press Release
VanEpps elected Fellow of the American College of Emergency Physicians
Congratulations to Scott VanEpps who was recently elected as a Fellow of the American College of Emergency Physicians.