Cell and Tissue Engineering
Scientists in the Cell and Tissue Engineering Cluster are inspired to better understand fundamental principles of cell biology and exploit this knowledge to regenerate tissues and treat debilitating human diseases.
These efforts are supported by the daily interaction among basic scientists, engineers, and clinicians that creates an environment to innovate and discover. Current lab groups focus in the areas of tissue engineering, the role of tissue remodeling in the progression of metabolic and cardiovascular diseases, and human pluripotent stem cell and cancer stem cell biology.
Tissue engineering projects include design and fabrication of biomaterials as cell, protein or gene delivery devices, genetic engineering to direct cell and protein activity, and the development of multi-tissue interfaces. The metabolic modeling group focuses on the role of extracellular matrix remodeling (ECM) in the regulation of metabolism. By using genetically modified mouse models, three-dimensional (3-D) tissue culture, they work to define the molecular mechanism by which 3-D ECM remodeling regulates transcription, differentiation, and metabolic function in vitro and in vivo. Projects in the pluripotent stem cell group focus on how constituents of cell signaling pathways regulate transcription factors to balance self-renewal and cell differentiation in both human embryonic stem cells and induced pluripotent stem cells. The cancer stem cell group has elucidated a number of intrinsic and extrinsic pathways that regulate self-renewal and cell fate decisions in cancer stem cells and is translating these pre-clinical research findings into the development of clinical trials designed to target breast cancer stem cells.
Related Press Releases & Articles
- March 20 @ 11:30 am
BI Research Day Registration
Join us for the inaugural BI Research Day and third annual Microposter Session on March 20, 2019.
- January 31, 2019 / Article
New article on a surgical grafting technique from the Keller Lab.
Evan Keller and collaborators from the Department of Urology publish a new article on a surgical grafting technique, for direct implantation of human cancer cells into the bladder lumen.
The article titled “A Surgical Orthotopic Approach to Study the Invasive Progression of Human Bladder Cancer” appears in Nature Protocol.
- January 21, 2019 / Award
Will Giannobile awarded 2018 Norton M. Ross Award by the American Dental Association
Dr. Giannobile is being recognized for his achievements in regenerative medicine and tissue engineering.
- October 31, 2018 / Article
Recent BI Publications
Recent publications from BI Research Groups
- October 23, 2018 / Article
Call for Nominations for BI Innovator Awards
The Biointerfaces Institute seeks nominations for its inaugural round of BI Innovator Awards.
The goal of the Innovator Award is to recognize faculty, graduate student and postdoctoral researchers who are active contributors to the interdisciplinary research, innovation and translational ecosystem at BI.
- October 22, 2018 / Award
Sunitha Nagrath wins ACS Award
Sunitha Nagrath is the recipient of the 2018 Analytical Chemistry Young Innovator Award. The award honors the contributions of an individual who has demonstrated exceptional technical advancement and innovation in the field of microfluidics or nanofluidics in his or her early career.
- October 3, 2018 / Article
Sunitha Nagrath publishes work on new microfluidic Carpet Chip
The article entitled “Profiling Heterogeneous Circulating Tumor Cells (CTC) Populations in Pancreatic Cancer Using a Serial Microfluidic CTC Carpet Chip” appears in Advanced Biosystems.
- June 22, 2018 / Award
Max Wicha named 2019 Henry Russel Lecturer
The Henry Russel Lectureship is awarded annually to a faculty member with exceptional achievements in research, scholarship or creative endeavors, as well as an outstanding record of teaching, mentoring and service.
- May 1, 2018 / Award
Congratulations Microposter Winners
Thank you to all of the poster presenters who attended the BIRG 2nd Microposter Session and congratulations to our winners!
- April 3, 2018 / Article
Carlos Aguilar wins Non-Tenured Faculty Award from 3M
Carlos Aguilar is one of the recipients of the 2018 3M Non-Tenured Faculty Awards. Awarded by 3M Corporation, this award recognizes junior faculty who demonstrate outstanding research, experience, teaching and academic leadership.
- March 14, 2018 / Press Release
Press Release – 3D Printing for Medicine
A collaborative project from the Lahann, Luker and Krebsbach labs reports on new jet writing technique for printing 3D structures for biomedical applications.
- March 1, 2018 / Article
Interdisciplinary team of BI researchers publish new article on 3-D Jet Writing Technique
The article entitled “3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures” appears in Advanced Materials.
- February 5, 2018 / Award
Two BI research fellows awarded MICHR Award
Patricia Schnepp, PhD and Vishwanath Sankarasubramanian, PhD receive Postdoctoral Translational Scholars Program (PTSP) Awards from MICHR.
- January 30, 2018 @ 12:00 pm
Marc Thurner, CEO of RegenHu, will be discussing the company’s line of 3D bioprinters.
- January 23, 2018 / Press Release
Diabetes and Its Complications Challenge Seed Funds Awards
We are pleased to announce our selection for the Diabetes and Its Complications Challenge seed fund competition.
- January 10, 2018 / Press Release
Carlos Aguilar joins BI
Carlos Aguilar, Assistant Professor of Biomedical Engineering, and his research group recently joined BI. The Nano-Omic-Bio-Engineering Lab (NOBEL) is working on developing new approaches and tools to understand and investigate skeletal muscles.
- November 29, 2017 / Press Release
Nanoparticles self-assemble into nanoshells
Research in the Kotov group demonstrated the self-assembly of inorganic nanoparticles into nanoshells, which can potentially be used for gene delivery applications. More details here.
- November 29, 2017 / Featured
Scaffold-Based Lung Organoid
Lonnie Shea’s research group developed scaffold technologies to grow lung organoids.
- September 27, 2017 / Article
Findings on Circulating Tumor Cells published in Cell Systems
A research article from Sunitha Nagrath’s lab, in collaboration with the Keller, Wicha and Simeone groups, entitled “High-Throughput Microfluidic Labyrinth for Label-free Isolation of Circulating Tumor Cells” was published in Cell Systems.
- September 25, 2017 / Press Release
Nagrath identifying new cancer targets
In work started during his time at Rice University, Deepak Nagrath continues to research cancer cell metabolism and how cancer cells interact. Learning how the cells communicate could lead to new targets for more effective treatments than those currently is use.