Advanced Materials and Drug Delivery
The Advanced Materials and Drug Delivery Cluster Area seeks to create and apply cutting-edge biomaterials for high-impact biomedical applications and to create paradigm-changing approaches and systems for advanced drug delivery.
Novel biomaterials are created to solve critical issues of the field: guide tissue regeneration, design highly selective, robust and biocompatible sensors, and alter surface chemistry to improve tissue/device interfaces. Likewise, we thrive to deliver difficult drugs (proteins, peptides, siRNA, insoluble anticancer drugs, vaccine antigens) in a targeted manner and to hard-to- reach places (cancer cells, brain, eye, lymph nodes) for prolonged periods of time (controlled release) in order to maximize therapeutic efficacy.
Our efforts in biomaterials include designing novel polymer-protein and polymer lipid composites for sensing of influenza virus, prostate cancer antigen and antibiotics. Surface engineering of biomaterials can lead to creation of non-wettable surfaces to control protein and cell adhesion, stem cell culture and differentiation. We blend and modify biocompatible polymers to improve mucoadhesion and stability of entrapped drug molecules. We cross-link phospholipid bilayers and develop lipid-peptide complexes to alter cell processing of biomaterials. We collectively contributed to an extensive toolbox of drug delivery platforms such as mucoadhesive gels, biodegradable implants, multicompartmental polymer nanoparticles, cross-linked liposomes for antigen delivery, and lipoprotein nanodisks. These platform technologies deliver a wide range of drug molecules and vaccine antigens with a focus on large molecule stability and delivery.
Multi-phasic particles of different shapes can be manufactured with precise control over particles geometry by the Wettability Engendered Templated Self-assembly (WETS) method.
Related Press Releases & Articles
- December 9, 2020 / Award
Nick Kotov Elected to National Academy of Inventors
Professor Nick Kotov was elected to the 2020 Class of Fellows by the National Academy of Inventors
- December 1, 2020 / Article
BI Recent Publications
Publications from BI Research Groups in November
- October 30, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in October
- September 30, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in September
- September 30, 2020 / Press Release
FDA awards $5M to establish new Center for Research on Complex Generics
Researchers from the University of Michigan and the University of Maryland were awarded a $5 million grant to establish a new Center for Research on Complex Generics. BI Faculty Professor Anna Schwendeman will be the center co-director along with Professor James Polli from the University of Maryland.
The center is funded by the FDA Office of Generic Drugs and aims at bringing complex generic drugs and drug products to market faster.
- July 31, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in July
- June 30, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in June
- June 18, 2020 / Award
Moon Awarded Michigan Drug Discovery Grant
Congratulations to James Moon who received a pilot grant from Michigan Drug Discovery to continue his ongoing work to develop immunotherapy agents for the treatment of cancer.
- May 29, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in May
- March 31, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in March
- March 2, 2020 / Award
2020 BI Innovator Awardees
Congratulations to the 2020 BI Innovator Award Recipients. BI Innovator awards recognize members of the BI research community who are active participants in the research, innovation and translational ecosystem at BI.
The 2020 awardees will be featured speakers at the BI Research Day on March 18.
- February 28, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in February
- January 31, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in January
- January 2, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in December
- December 18, 2019 / Award
BI Teams Receive Biosciences Initiative Awards
Three major research initiatives projects were awarded to BI faculty in the latest round of funding from the Biosciences Initiative
- December 12, 2019 / Article
Call for Nominations for BI Innovator Awards
The Biointerfaces Institute seeks nominations for its annual BI Innovator Awards.
The goal of the Innovator Award is to recognize faculty, graduate student and postdoctoral researchers who are active contributors to the interdisciplinary research, innovation and translational ecosystem at BI.
- December 4, 2019 / Article
Recent BI Publications
Publications from BI Research Groups in November
- November 25, 2019 / Translational Research
BI Startup EVOQ Therapeutics wins Grand Prize at Accelerate Michigan Innovation Competition
EVOQ Therapeutics, an Ann Arbor-based startup focused on developing cancer immutherapies, has won the grand prize at the tenth Accelerate Michigan Innovation Competition. The company is based on technology developed by BI faculty members, James Moon and Anna Schwendeman.
- October 31, 2019 / Article
Recent BI Publications
Publications from BI Research Groups in October
- October 23, 2019
43rd Annual Macro Symposium
The Macro Symposium brings together students, faculty, alumni, and industry professionals for two days of invited talks, professional and academic development courses, poster presentations, and a networking dinner. Last year, we hosted over 150 participants representing 10 companies, 8 departments at Michigan, and 25 institutions across the country.
Our Advanced Materials and Drug Delivery Researchers
Single Cell Technologies
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James Moon
John Gideon Searle Associate Professor of Pharmaceutical Sciences; Associate Professor: Biomedical Engineering Research Focus: Advanced Materials and Drug Delivery Contact Information:moonjj@umich.eduThe Moon Group develops therapeutics and diagnostics at the interface of immunology and engineering. Research addresses drug delivery systems for enhancing delivery of antigen and adjuvant to lymphoid organs and manipulating immune functions in the context of cancer, infectious diseases, and autoimmunity.
Anish Tuteja
Associate Professor of Materials Science and Engineering and Macromolecular Science and Engineering Research Focus: Advanced Materials and Drug Delivery Contact Information:atuteja@umich.eduThe Tuteja Group research is in surface science, including developing super-omniphobic surfaces (surfaces on which liquids bead up and roll- off). They have developed a novel technique to fabricate nano- and micro- particles of any size, shape, or chemistry. The developed particles’ shape, size, and composition can be used to engineer bio-distribution, skin or lung uptake, intra-cellular localization, and cell response.
Steven Schwendeman
Ara G. Paul Professor and Department Chair of Pharmaceutical Sciences; Professor of Biomedical Engineering Research Focus: Advanced Materials and Drug Delivery Contact Information:schwende@umich.eduThe Schwendeman Group develops advanced polymer-based controlled drug delivery approaches including vaccine delivery from poly(lactic-co-glycolic acid) (PLGA); PLGA nanoparticle formulation; and development of mucoadhesive polymers/formulations for intraoral and intranasal delivery.
Joerg Lahann
Wolfgang Pauli Collegiate Professor of Chemical Engineering; Professor of Materials Science and Engineering, Biomedical Engineering, and Macromolecular Science and Engineering Research Focus: Advanced Materials and Drug Delivery, Single Cell Technologies Contact Information:lahann@umich.eduResearch in the Lahann Lab focuses on surface engineering, advanced polymers, biomimetic materials, engineered stem cell microenvironments, drug delivery, and nano-scale self-assembly.
Peter Tessier
Albert M. Mattocks Professor of Pharmaceutical Sciences and Chemical Engineering Research Focus: Advanced Materials and Drug Delivery, Nanotechnology Contact Information:ptessier@umich.eduThe Tessier lab aims to develop next generation technologies for designing, discovering, engineering, characterizing, formulating and delivering biologics ranging from small affinity peptides to large monoclonal antibodies for molecular imaging, diagnostic and therapeutic applications.
Jinsang Kim
Professor of Materials Science and Engineering, Chemical Engineering, Biomedical Engineering, and Macromolecular Science and Engineering and Director of Macromolecular Science and Engineering Program Research Focus: Advanced Materials and Drug Delivery Contact Information:jinsang@umich.eduKim’s Smart Functional Polymer Lab explores functional polymeric materials and their nanostructural assembly to develop advanced polymeric objects. The research focuses on the rational molecular design, chemical and/or biological synthesis, and molecular assembly of functional polymers.