Advanced Materials and Drug Delivery
The Advanced Materials and Drug Delivery Cluster Area seeks to create and apply cutting-edge biomaterials for high-impact biomedical applications and to create paradigm-changing approaches and systems for advanced drug delivery.
Novel biomaterials are created to solve critical issues of the field: guide tissue regeneration, design highly selective, robust and biocompatible sensors, and alter surface chemistry to improve tissue/device interfaces. Likewise, we thrive to deliver difficult drugs (proteins, peptides, siRNA, insoluble anticancer drugs, vaccine antigens) in a targeted manner and to hard-to- reach places (cancer cells, brain, eye, lymph nodes) for prolonged periods of time (controlled release) in order to maximize therapeutic efficacy.
Our efforts in biomaterials include designing novel polymer-protein and polymer lipid composites for sensing of influenza virus, prostate cancer antigen and antibiotics. Surface engineering of biomaterials can lead to creation of non-wettable surfaces to control protein and cell adhesion, stem cell culture and differentiation. We blend and modify biocompatible polymers to improve mucoadhesion and stability of entrapped drug molecules. We cross-link phospholipid bilayers and develop lipid-peptide complexes to alter cell processing of biomaterials. We collectively contributed to an extensive toolbox of drug delivery platforms such as mucoadhesive gels, biodegradable implants, multicompartmental polymer nanoparticles, cross-linked liposomes for antigen delivery, and lipoprotein nanodisks. These platform technologies deliver a wide range of drug molecules and vaccine antigens with a focus on large molecule stability and delivery.
Multi-phasic particles of different shapes can be manufactured with precise control over particles geometry by the Wettability Engendered Templated Self-assembly (WETS) method.
Related Press Releases & Articles
- June 28, 2019 / Article
Recent BI Publications
Recent Publications from BI Research Groups
- June 28, 2019 / Featured
Lahann and Technion collaborators report on scaffold system to study sprouting blood vessels
The team developed 3D scaffold systems with tessellated compartment geometries and a two-step seeding technique to model and study vessel sprouting decisions.
- May 30, 2019 / Article
Recent BI Publications
Recent Publications from BI Research Groups
- April 3, 2019 / BIRG
2019 BI Research Day
The inaugural BI Research Day and third annual microposter session was a huge success! Thank you to all who participated.
- March 20 @ 10:00 am
BI Research Day Registration
Join us for the inaugural BI Research Day and third annual Microposter Session on March 20, 2019.
- March 4, 2019 / Award
BI Innovator Awards Recipients
The inaugural 2019 BI Innovator Awards are awarded to Tim Bruns, Yichun Wang and Rose Cersonsky.
- February 22, 2019 / Translational Research
UM Invests in BI Startup Greenmark Biomedical
Through the Michigan Investment in New Technology Startups (MINTS) initiative, UM will invest $500K in GreenMark Medical, a startup based on technologies developed by BI Director, Joerg Lahann.
- January 21, 2019 / Article
S. Schwendeman publishes collaborative research on long-active contraceptive delivery
A new publication from Steve Schwendeman and his collaborators from Georgia Tech appears in Nature Biomedical Engineering and features micro-needle patches for long-acting contraceptive delivery.
- January 10, 2019 / Press Release
Kotov Lab draws inspiration from cartilage to develop new battery technology
Latest research findings from the Kotov lab on new structural batteries that are inspired by cartilage.
- January 3, 2019 / Translational Research
BI Startup Evoq Therapeutics profiled in Crain’s Detroit
Crain’s Detroit features Evoq Therapeutics, a startup company co-founded by James Moon and Anna Schwendeman.
- December 11, 2018 / Award
Maria Fawaz and Minzhi Yu receive AHA Predoctoral Fellowships
Maria Fawaz and Minzhi Yu, both graduate students in Anna Schwendeman’s group, have been awarded predoctoral fellowships from the American Heart Association.
- October 31, 2018 / Article
Recent BI Publications
Recent publications from BI Research Groups
- October 23, 2018 / Article
Call for Nominations for BI Innovator Awards
The Biointerfaces Institute seeks nominations for its inaugural round of BI Innovator Awards.
The goal of the Innovator Award is to recognize faculty, graduate student and postdoctoral researchers who are active contributors to the interdisciplinary research, innovation and translational ecosystem at BI.
- August 21, 2018 / Award
James Moon Earns 2018 AAPS Emerging Leader Award
This award recognizes scientists and pharmaceutical professionals who are early in their careers, who have made a significant impact in the pharmaceutical sciences that promotes public health.
- May 21, 2018 / Award
Chestek, Moon and A. Schwendeman Promoted
Cindy Chestek (Biomedical Engineering), James Moon (Pharmaceutical Sciences) and A. Schwendeman (Pharmaceutical Sciences) were promoted to Associate Professor with tenure. Congratulations!
- May 3, 2018 / Article
Tessier elected to the AIMBE College of Fellows Class of 2018
Peter Tessier was elected a Fellow of the American Institute for Medical and Biological Engineering (AIMBE). AIMBE comprises of leaders in medical and biological engineering, consisting of academic, industrial, professional society councils and elected fellows.
- May 1, 2018 / Award
Congratulations Microposter Winners
Thank you to all of the poster presenters who attended the BIRG 2nd Microposter Session and congratulations to our winners!
- April 25, 2018 / Award
Kevin Golovin receives ProQuest Distinguished Dissertation Award
The ProQuest Distinguished Dissertation Award recognizes exceptional and unusually interesting work produced by doctoral students from the Rackham School of Graduate Studies.
- April 16, 2018 / YouTube Video
Tuteja lab reports on new omniphobic coatings that repel almost everything
In a paper recently published in ACS Applied Materials & Interfaces, the Tuteja lab reports on recent findings on omniphobic coatings that could be applied on a variety of surfaces to repel almost any liquid.
- April 2, 2018 @ 1:00 pm
Oral PhD Defense – Lukasz Ochyl
Title: “Preparation and Characterization of Cell Membranes for Cancer Immunotherapy”
Lukasz Ochyl, Department of Pharmaceutical Sciences
Chair: James Moon
Our Advanced Materials and Drug Delivery Researchers
Nanotechnology
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Peter Tessier
Albert M. Mattocks Professor of Pharmaceutical Sciences and Chemical Engineering Research Focus: Nanotechnology, Advanced Materials and Drug Delivery Contact Information:ptessier@umich.eduThe Tessier lab aims to develop next generation technologies for designing, discovering, engineering, characterizing, formulating and delivering biologics ranging from small affinity peptides to large monoclonal antibodies for molecular imaging, diagnostic and therapeutic applications.
James Moon
John Gideon Searle Associate Professor of Pharmaceutical Sciences; Associate Professor: Biomedical Engineering Research Focus: Advanced Materials and Drug Delivery Contact Information:moonjj@umich.eduThe Moon Group develops therapeutics and diagnostics at the interface of immunology and engineering. Research addresses drug delivery systems for enhancing delivery of antigen and adjuvant to lymphoid organs and manipulating immune functions in the context of cancer, infectious diseases, and autoimmunity.
Anish Tuteja
Associate Professor of Materials Science and Engineering and Macromolecular Science and Engineering Research Focus: Advanced Materials and Drug Delivery Contact Information:atuteja@umich.eduThe Tuteja Group research is in surface science, including developing super-omniphobic surfaces (surfaces on which liquids bead up and roll- off). They have developed a novel technique to fabricate nano- and micro- particles of any size, shape, or chemistry. The developed particles’ shape, size, and composition can be used to engineer bio-distribution, skin or lung uptake, intra-cellular localization, and cell response.
Jinsang Kim
Professor of Materials Science and Engineering, Chemical Engineering, Biomedical Engineering, and Macromolecular Science and Engineering and Director of Macromolecular Science and Engineering Program Research Focus: Advanced Materials and Drug Delivery Contact Information:jinsang@umich.eduKim’s Smart Functional Polymer Lab explores functional polymeric materials and their nanostructural assembly to develop advanced polymeric objects. The research focuses on the rational molecular design, chemical and/or biological synthesis, and molecular assembly of functional polymers.
Joerg Lahann
Wolfgang Pauli Collegiate Professor of Chemical Engineering; Professor of Materials Science and Engineering, Biomedical Engineering, and Macromolecular Science and Engineering Research Focus: Advanced Materials and Drug Delivery, Single Cell Technologies Contact Information:lahann@umich.eduResearch in the Lahann Lab focuses on surface engineering, advanced polymers, biomimetic materials, engineered stem cell microenvironments, drug delivery, and nano-scale self-assembly.
Steven Schwendeman
Ara G. Paul Professor and Department Chair of Pharmaceutical Sciences; Professor of Biomedical Engineering Research Focus: Advanced Materials and Drug Delivery Contact Information:schwende@umich.eduThe Schwendeman Group develops advanced polymer-based controlled drug delivery approaches including vaccine delivery from poly(lactic-co-glycolic acid) (PLGA); PLGA nanoparticle formulation; and development of mucoadhesive polymers/formulations for intraoral and intranasal delivery.