Advanced Materials and Drug Delivery
The Advanced Materials and Drug Delivery Cluster Area seeks to create and apply cutting-edge biomaterials for high-impact biomedical applications and to create paradigm-changing approaches and systems for advanced drug delivery.
Novel biomaterials are created to solve critical issues of the field: guide tissue regeneration, design highly selective, robust and biocompatible sensors, and alter surface chemistry to improve tissue/device interfaces. Likewise, we thrive to deliver difficult drugs (proteins, peptides, siRNA, insoluble anticancer drugs, vaccine antigens) in a targeted manner and to hard-to- reach places (cancer cells, brain, eye, lymph nodes) for prolonged periods of time (controlled release) in order to maximize therapeutic efficacy.
Our efforts in biomaterials include designing novel polymer-protein and polymer lipid composites for sensing of influenza virus, prostate cancer antigen and antibiotics. Surface engineering of biomaterials can lead to creation of non-wettable surfaces to control protein and cell adhesion, stem cell culture and differentiation. We blend and modify biocompatible polymers to improve mucoadhesion and stability of entrapped drug molecules. We cross-link phospholipid bilayers and develop lipid-peptide complexes to alter cell processing of biomaterials. We collectively contributed to an extensive toolbox of drug delivery platforms such as mucoadhesive gels, biodegradable implants, multicompartmental polymer nanoparticles, cross-linked liposomes for antigen delivery, and lipoprotein nanodisks. These platform technologies deliver a wide range of drug molecules and vaccine antigens with a focus on large molecule stability and delivery.
Related Press Releases & Articles
- April 16, 2018 / YouTube Video
Tuteja lab reports on new omniphobic coatings that repel almost everything
In a paper recently published in ACS Applied Materials & Interfaces, the Tuteja lab reports on recent findings on omniphobic coatings that could be applied on a variety of surfaces to repel almost any liquid.
- April 2 @ 1:00 pm
Oral PhD Defense – Lukasz Ochyl
Title: “Preparation and Characterization of Cell Membranes for Cancer Immunotherapy”
Lukasz Ochyl, Department of Pharmaceutical Sciences
Chair: James Moon
- March 14, 2018 / Press Release
Press Release – 3D Printing for Medicine
A collaborative project from the Lahann, Luker and Krebsbach labs reports on new jet writing technique for printing 3D structures for biomedical applications.
- March 1, 2018 / Article
Interdisciplinary team of BI researchers publish new article on 3-D Jet Writing Technique
The article entitled “3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures” appears in Advanced Materials.
- February 22 @ 2:00 pm
Seminar on “Materials for Biodegradable Electronics” – John Rogers, Northwestern University
This event is co-hosted by the University of Michigan ACS POLY/PMSE Student Chapter and the Biointerfaces Institute Researcher Group.
- February 21, 2018 / YouTube Video
Kotov awarded Gold Prize Award in the Mobile World Scholar Challenge
Nick Kotov’s work on biomimetic composites is recognized by the Mobile World Scholar Challenge
- January 30 @ 12:00 pm
Marc Thurner, CEO of RegenHu, will be discussing the company’s line of 3D bioprinters.
- January 25, 2018 / Featured
New Science Article from the Kotov Lab
The article entitled “Chiromagnetic Nanoparticles and Gels” appeared in the January 19 issue of Science.
- January 23, 2018 / Press Release
Diabetes and Its Complications Challenge Seed Funds Awards
We are pleased to announce our selection for the Diabetes and Its Complications Challenge seed fund competition.
- November 29, 2017 / Press Release
Nanoparticles self-assemble into nanoshells
Research in the Kotov group demonstrated the self-assembly of inorganic nanoparticles into nanoshells, which can potentially be used for gene delivery applications. More details here.
- November 29, 2017 / Featured
Scaffold-Based Lung Organoid
Lonnie Shea’s research group developed scaffold technologies to grow lung organoids.
- November 29, 2017 / Featured
Nick Kotov develops artificial cartilage materials from Kevlar-based nanofibers.
- October 31, 2017 / Press Release
Tuteja Lab – PSI Group
Research in the Polymers Interfaces Surfaces (PSI) Group directed by Prof. Anish Tuteja focuses on developing polymers for energy and environmental applications. To date, the group has developed polymer systems for:
Superhydrophobic and superoleophobic surfaces
- October 11, 2017 / Article
An article co-authored by Green, Larson and Solomon published in Physical Review Letters
Joint research in the Green, Larson and Solomon groups published in Physical Review Letters in an article entitled “Rheological State Diagrams for Rough Colloids in Shear Flow”.
- October 3, 2017 / Article
A. Schwendeman and S. Schwendeman publishes work in MAb
The article entitled “Biosimilarity under stress: A forced degradation study of Remicade® and Remsima™” appeared in MAb.
- October 1, 2017 / Article
James Moon publishes work on a gold nanoparticle-based delivery platform
The article “Adjuvant-Loaded Spiky Gold Nanoparticles for Activation of Innate Immune Cells” appears in Cellular and Molecular Engineering.
- September 18, 2017 / Article
Report on the role of branched nanofibers in 3-dimensional networks
An article co-authored by N. Kotov and P. Green reports on the role of branched aramid nanofibers in three-dimensional network. The article appeared in Angewandte Chemie.
- September 12, 2017 / Press Release
Lahann part of newly awarded NSF-ERC center
BI director, Joerg Lahann, is part of the U-M team for the newly announced NSF Engineering Research Center (ERC). Led by Boston University, the NSF-ERC aims to grow new heart tissues. For more details on the award and team, please visit here.
- September 6, 2017 / Article
Joint Moon and A. Schwendeman research on HDL nanodisks
The article entitled “Synthetic high-density lipoprotein nanodisks for targeted withalongolide delivery to adrenocortical carcinoma” was published in International Journal of Nanomedicine.
- September 5, 2017 / Article
S. Schwendeman and J. Moon report on PLGA based formulation for vaccine delivery
The findings are published in an article entitled “Self-encapsulating PLGA Microspheres for Intranasal Vaccine Delivery” in Molecular Pharmaceutics.