Single Cell Technologies
This cluster focuses on the development of methods and technologies to probe a single cell.
This goal of this cluster is to build a synergistic scientific and technological platform to investigate one of the most critical building blocks of any biological system – a cell. Through the convergence of biology, computational approaches and engineering, the cluster addresses fundamental biological questions on cellular heterogeneity by developing integrated approaches and technologies to isolate, preserve, characterize and expand rare cells. This approach will enable investigation of basic biological components of single cells at a higher resolution and holds the promise of transforming the study, diagnosis and treatment of every disease. The cluster builds upon an existing ecosystem of UM investigators with complementary research excellence and active collaborations from engineering, physical sciences, life sciences and the medical school.
Recent Publications
Three-dimensional (3D) adipose tissue organoids for disease modeling. Lipid (red), actin (green), nucleus (blue).
Cell in an engineered scaffold
Related Press Releases & Articles
- August 3, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in July
- July 9, 2020 / Article
Study by Deepak Nagrath and Sunitha Nagrath Labs propose new strategy to target pancreatic cancer
Study by Deepak Nagrath and Sunitha Nagrath Labs propose new strategy to target pancreatic cancer
- May 7, 2020 / Award
Deepak Nagrath Named Forbes Scholar
Congratulations to Deepak Nagrath on being named one of the Rogel Cancer Center’s 2020 Forbes Scholars. Nagrath is using genetic and clinical data from patients to identify mutations in ovarian cancer cells.
- March 2, 2020 / Award
2020 BI Innovator Awardees
Congratulations to the 2020 BI Innovator Award Recipients. BI Innovator awards recognize members of the BI research community who are active participants in the research, innovation and translational ecosystem at BI.
The 2020 awardees will be featured speakers at the BI Research Day on March 18.
- January 31, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in January
- January 2, 2020 / Article
Recent BI Publications
Publications from BI Research Groups in December
- December 18, 2019 / Award
BI Teams Receive Biosciences Initiative Awards
Three major research initiatives projects were awarded to BI faculty in the latest round of funding from the Biosciences Initiative
- December 12, 2019 / Article
Call for Nominations for BI Innovator Awards
The Biointerfaces Institute seeks nominations for its annual BI Innovator Awards.
The goal of the Innovator Award is to recognize faculty, graduate student and postdoctoral researchers who are active contributors to the interdisciplinary research, innovation and translational ecosystem at BI.
- October 31, 2019 / Article
Recent BI Publications
Publications from BI Research Groups in October
- September 30, 2019 / Article
Recent BI Publications
Publications from BI Research Groups in September
- September 4, 2019 / Translational Research
Cardiovascular Diseases Challenge Seed Fund Awards
We are pleased to announce the funding selections for the BI Engineering Approaches to Cardiovascular Diseases Challenge.
- August 30, 2019 / Article
Recent BI Publications
Recent Publications from BI Research Groups
- July 1, 2019 / Article
Graduate Student Ziwen Zhu receives 2019 Precision Health Scholar Award
Ziwen Zhu, a graduate student in Biomedical Engineering from Deepak Nagrath’s lab, has received one of the 2019 Precision Health Scholar Awards for his project titled “Metabolic Liquid Biopsy to Predict Treatment Response in Non Small Cell Lung Cancer”
- June 28, 2019 / Article
Recent BI Publications
Recent Publications from BI Research Groups
- May 30, 2019 / Article
Recent BI Publications
Recent Publications from BI Research Groups
- May 20, 2019 / Award
Sunitha Nagrath named Rogel Scholar
Congratulations to Sunitha Nagrath on being in the inaugural class of Rogel Scholars!
- April 3, 2019 / BIRG
2019 BI Research Day
The inaugural BI Research Day and third annual microposter session was a huge success! Thank you to all who participated.
- March 20, 2019 @ 10:00 am
BI Research Day Registration
Join us for the inaugural BI Research Day and third annual Microposter Session on March 20, 2019.
- March 4, 2019 / Award
BI Innovator Awards Recipients
The inaugural 2019 BI Innovator Awards are awarded to Tim Bruns, Yichun Wang and Rose Cersonsky.
- January 31, 2019 / Article
New article on a surgical grafting technique from the Keller Lab.
Evan Keller and collaborators from the Department of Urology publish a new article on a surgical grafting technique, for direct implantation of human cancer cells into the bladder lumen.
The article titled “A Surgical Orthotopic Approach to Study the Invasive Progression of Human Bladder Cancer” appears in Nature Protocol.
Our Single Cell Technologies Researchers
Cell and Tissue Engineering
Learn MoreNanotechnology
Learn MoreAdvanced Materials and Drug Delivery
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Nicholas Kotov
Joseph B. and Florence V. Cejka Professor of Engineering; Professor of Chemical Engineering, Materials Science and Engineering, Biomedical Engineering, and Macromolecular Science and Engineering Research Focus: Single Cell Technologies, Nanotechnology Contact Information:kotov@umich.eduResearch in the Kotov Group focuses on self-organization of nanocolloids, layer-by-layer assembly, ultrastrong nanocomposites, tissue engineering with nanomaterials, nanoscale drugs, and implantable biomedical devices.
Carlos Aguilar
Assistant Professor of Biomedical Engineering Research Focus: Single Cell Technologies, Cell and Tissue Engineering Contact Information:caguilar@umich.eduAguilar’s NOBEL lab develops, optimizes and applies innovative technologies such as integrative genomic assays and high-throughput sequencing, micro/nanofabricated devices, genome editing and computational modeling to its primary area of focus, which is skeletal muscle.
Deepak Nagrath
Associate Professor of Biomedical Engineering Research Focus: Cell and Tissue Engineering, Single Cell Technologies Contact Information:dnagrath@umich.eduThe Nagrath lab focuses on both experimental and theoretical aspects of Cellular and Molecular Tissue Engineering, Metabolic Engineering, and Biomedicine with emphasis on clinical applications. Our research interests lie in the systems biology of metabolic diseases, specifically cancer.
Joerg Lahann
Wolfgang Pauli Collegiate Professor of Chemical Engineering; Professor of Materials Science and Engineering, Biomedical Engineering, and Macromolecular Science and Engineering Research Focus: Advanced Materials and Drug Delivery, Single Cell Technologies Contact Information:lahann@umich.eduResearch in the Lahann Lab focuses on surface engineering, advanced polymers, biomimetic materials, engineered stem cell microenvironments, drug delivery, and nano-scale self-assembly.
Evan Keller
Professor of Urology and Pathology; Associate Professor of Comparative Pathology Research Focus: Single Cell Technologies, Cell and Tissue Engineering Contact Information:etkeller@umich.eduThe Keller Group focuses on the biology of cancer metastasis and explores genes that regulate metastasis and the interaction between the bone microenvironment and cancer cells. Researchers perform translational studies to enable movement of research findings into clinics.
Max Wicha
Madeline and Sidney Forbes Professor of Oncology Research Focus: Cell and Tissue Engineering, Single Cell Technologies Contact Information:mwicha@umich.eduWicha researchers study the biology of stem cells in the normal mammary gland and breast cancers by isolating and characterizing normal and malignant mammary stem cells and the changes in these key cells during carcinogenesis.
Sunitha Nagrath
Associate Professor of Chemical Engineering Research Focus: Single Cell Technologies, Cell and Tissue Engineering Contact Information:snagrath@umich.eduThe Nagrath lab research focuses on developing integrated nano- and microfluidic technologies for understanding cell trafficking in cancer through isolation, characterization, and the study of circulating tumor cells in peripheral blood of cancer patients.