Research Publications
Scholarly Contributions
BI researchers are at the forefront of their field and combine their expertise to tackle the most complex biomedical questions. They are active contributors to the scholarly mission of our institute and training the next generation of scientists.
BI Impact
BI researchers are active contributors to the university’s research mission: engaging in scientific discovery and entrepreneurship across the institute and the entire campus. At BI, we are making scholarly impact and technological strides, while training the next generation of biomedical engineers.
Research Accomplishments
$140M
in research expenditures since 2012
$1.7M
Distribution In Seed Funding To 25+ Multi-Disciplinary Teams
9
Department Challenges Organized That Brought Together 350+ Participants
Since 2012 BI Researchers Have Participated In
1700+ Publications
120,000+ Citations
200+
Inventions
126
Issued Patents
11
New Startups
Recent Publications
View a listing of the most recent BI publications here
Advanced Materials and Drug Delivery
- Analytical method development and comparability study for AmBisome® and generic Amphotericin B liposomal products (A. Schwendeman)
- Cancer immunotherapy via targeting cancer stem cells using vaccine nanodiscs (Moon, A. Schwendeman & Wicha)
- Characterization of octreotide-PLGA binding by isothermal titration calorimetry (S. Schwendeman)
- Efficient lymph node-targeted delivery of personalized cancer vaccines with reactive oxygen species-inducing reduced graphene oxide nanosheets (Moon)
- Lysis and direct detection of coliforms on printed paper-based microfluidic devices (Tuteja & VanEpps)
- Molecular changes in vapor‐based polymer thin films assessed by characterization of swelling properties of amine‐functionalized poly‐p‐xylylene (Lahann)
- Multifunctional synthetic protein nanoparticles via reactive electrojetting (Lahann)
- Physical-chemical characterization of octreotide encapsulated in commercial glucose-star PLGA microspheres (S. Schwendeman)
- Programmable delivery of synergistic cancer drug combinations using bicompartmental nanoparticles (Lahann)
- Self-encapsulating poly(lactic-co-glycolic acid) (PLGA) microspheres for intranasal vaccine delivery (Moon & S. Schwendeman)
- Rational design of transparent nanowire architectures with tunable geometries for preventing marine fouling (Tuteja)
- Effect of nanoparticle composition, size, shape, and stiffness on penetration across the blood-brain barrier (Lahann)
- Engineered ovalbumin nanoparticles for cancer immunotherapy (Lahann & Moon)
- Enzyme scaffolds with hierarchically defined properties via 3D jet writing (Lahann)
- Improving STING agonist delivery for cancer immunotherapy using biodegradable mesoporous silica nanoparticles (Moon)
- On demand light-degradable polymers based on 9,10-dialkoxyanthracenes (Lahann)
Cell and Tissue Engineering
- Acute implantation of aligned hydrogel tubes supports delayed spinal progenitor implantation (Shea)
- CERE-120 prevents irradiation-induced hypofunction and restores immune homeostasis in porcine salivary glands (Lombaert)
- Development of a nomogram for the prediction of periodontal tooth loss using the staging and grading system: a long‐term cohort study (Giannobile)
- Integration of islet/beta-cell transplants with host tissue using biomaterial platforms (Shea)
- Saliva in the diagnosis of COVID-19: a review and new research directions (Lombaert)
- Dissecting murine muscle stem cell aging through regeneration using integrative genomic analysis (Aguilar)
- Dual-isolation and profiling of circulating tumor cells and cancer exosomes from blood samples with melanoma using immunoaffinity-based microfluidic interfaces (S. Nagrath)
- Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis (Shea)
- Extracellular vesicles on demand (EVOD) chip for screening and quantification of cancer-associated extracellular vesicles (S. Nagrath)
- Modeling, identification, and flow control for a microfluidic device using a peristaltic pump (S. Nagrath)
- Preclinical assessment of clinically streamlined, 3D‐printed, biocompatible single‐ and two‐stage tissue scaffolds for ear reconstruction (Lombaert)
- Regulation of adipose tissue inflammation and systemic metabolism in murine obesity by polymer implants loaded with lentiviral vectors encoding human interleukin‐4 (Shea)
- Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells (Aguilar)
- Hydrogel and neural progenitor cell delivery supports organotypic fetal spinal cord development in an ex vivo model of prenatal spina bifida repair (Shea)
- Increased expression of interleukin-1 receptor characterizes anti-estrogen-resistant ALDH+ breast cancer stem cells (Wicha)
- ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment (D. Nagrath)
- Peri‐implant soft tissue phenotype modification and its impact on peri‐implant health: A systematic review and network meta‐analysis (Giannobile)
- Simultaneous single cell gene expression and EGFR mutation analysis of circulating tumor cells reveals distinct phenotypes in NSCLC (Keller & S. Nagrath)
- Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours (D. Nagrath & S. Nagrath)
Nanotechnology
- An experimentally validated heat and mass transfer model for wax deposition from flowing oil onto a cold surface (Larson)
- Effect of flow-induced nematic order on polyethylene crystal nucleation (Larson)
- Experimental investigation of time-dependent thickness and composition of multi-component wax deposits on cold surfaces (Larson)
- Omnidispersible microscale colloids with nanoscale polymeric spikes (Kotov)
- A mean-field approach to simulating anisotropic particles (Glotzer)
- Analysis of partitioning of salt through doping of polyelectrolyte complex coacervates (Larson)
- Biomorphic structural batteries for robotics (Kotov)
- Differential effects of heated perfusate on morphology, viability, and dissemination of Staphylococcus epidermidis biofilms (Solomon & VanEpps)
- Hybrid antimicrobial hydrogel as injectable therapeutics for oral infection ablation (A. Schwendeman)
- Inverse design of compression-induced solid – solid transitions in colloids (Glotzer)
- A slip-spring simulation model for predicting linear and nonlinear rheology of entangled wormlike micellar solutions (Larson)
- HOOMD-blue version 3.0 a modern, extensible, flexible, object-oriented API for molecular simulations (Glotzer)
Neural Engineering
- An implantable microelectrode array for chronic in vivo epiretinal stimulation of the rat retina (Weiland)
- Comparison of signal decomposition techniques for analysis of human cortical signals (Chestek & Stacey)
- Crosswalk guidance system for the blind (Weiland)
- Distinguishing false and true positive detections of high frequency oscillations (Stacey)
- Preictal variability of high‐frequency oscillation rates in refractory epilepsy (Stacey)
- A low-power band of neuronal spiking activity dominated by local single units improves the performance of brain–machine interfaces (Chestek)
- Functional magnetic resonance imaging correlates of ventral striatal deep brain stimulation for poststroke pain (Lempka)
- High density carbon fiber arrays for chronic electrophysiology, fast scan cyclic voltammetry, and correlative anatomy (Chestek)
- Magnetic resonance imaging of human neural stem cells in rodent and primate brain (Chestek)
- A patient-specific computational framework for the Argus II implant (Lempka & Weiland)
- Estimating risk for future intracranial, fully implanted, modular neuroprosthetic systems: A systematic review of hardware complications in clinical deep brain stimulation and experimental human intracortical arrays (Chestek)
- Real-time pattern recognition of finger movements using regenerative peripheral nerve interfaces and implanted electrodes (Chestek)