This work uncovers autophagy as a critical pathwayfor survival in mIDH1 gliomas and its inhibition elicits radiosensitivity in vitro inhuman and mouse mIDH1 glioma cells, and in vivo in mIDH1 models.

Calling all entrepreneurs! Innovation Partnerships recently announced the launch of the third cohort of the Accelerate Blue Foundry.

The A-B Foundry matches entrepreneurs with world-class technologies developed at the University of Michigan. If matched with a technology, entrepreneurs will partner with U-M inventors over five months to develop a business case and pitch for a new startup. The A-B Foundry will provide educational programming, mentorship, networking opportunities, and pitch practice to help entrepreneurs prepare. 

The Accelerate Blue Fund has committed to invest at least $50,000 in each credible startup coming out of the Foundry.

Date: Friday, September 25, 2026
Time: 2:30 PM
Location: Kahn Auditorium, A. Alfred Taubman Biomedical Sciences Research Building (BSRB)

Announcing a special symposium celebrating the naming of the Scott Pranger ALS Center!

The event will feature a recorded discussion with Sanjay Gupta, M.D., the award-winning chief medical correspondent for CNN, on pain, an often overlooked burden for those living with ALS.

Date: Friday, October 2, 2026
Time: 9:00 AM – 5:00 PM
Location: NCRC Building 18, Dining Hall

This full-day symposium will bring together leading researchers and innovators in spatial biology, spatial omics, imaging, genomics, and computational analytics for a day of scientific presentations, networking, and collaboration with opportunities for Trainees to highlight their latest research as well!

Congratulations to BI Core Faculty, Jae-Won Shin and Sunitha Nagrath, on being awarded a grant from the new Strategic Initiative Fund (SIF) from University of Michigan! This grant will be used to create the Michigan Center for Extracellular Nanomedicine (MCEN).

Dr. Feldman currently serves as the James W. Albers Distinguished University Professor and Russell N. DeJong Professor of Neurology. She is also Director of the NeuroNetwork for Emerging Therapies and the Scott Pranger ALS Center at Michigan Medicine.

The Feldman lab focuses on understanding the mechanisms underlying neurodegenerative and neuromuscular diseases, with particular interests in amyotrophic lateral sclerosis (ALS) and the neurological complications of metabolic dysfunction, including peripheral neuropathy and dementia. The lab also develops innovative therapeutic strategies to prevent and treat these diseases.

From agricultural waste to carbon-negative chemicals, Dr. Anthony Berardi’s journey with Citrimer highlights how resourcefulness and persistence can help move an idea from concept to startup.

Dr. Matthew Willsey, who led the surgery, said the research could represent an important step toward improving communication options for people with paralysis who have limited effective treatment options.

The National Institutes of Health (NIH) has awarded a five-year grant expected to total approximately $2.5 million to U-M researchers, with an aim to engineer precision biomaterials to track, recruit, and study specialized immune cells. The project is a collaborative effort featuring Aaron Morris, Assistant Professor, Biomedical Engineering, and co-investigator James Moon, the J.G. Searle Professor of Pharmaceutical Sciences in the College of Pharmacy, and Professor, Biomedical Engineering and Chemical Engineering in the College of Engineering.

Immune-relevant proteins are important drug targets, and many are redox-regulated. A chemoproteomics-driven annotation of redox-regulated immune-relevant proteins and ligand discovery effort led to the development of covalent allosteric modulators targeting a redox-sensitive cysteine in SHP1, a protein tyrosine phosphatase that negatively regulates immune signaling.

Nanomaterials can manifest new material properties when clusters of nanoparticle crystals are connected by more randomly distributed particles. In many nanoparticle systems, graph theory offers a framework to quantify and tune complexity, defined as the mix of order and randomness. The findings bring University of Michigan Engineering’s Center for Complex Particle Systems closer to its goal of designing bio-inspired materials with properties rarely, if ever, seen in nature.

At an ultralow intravenous dose (0.003 milligrams per kilogram), CRYSTAL activated STING in mice, dogs, and nonhuman primates without cytokine release syndrome. CRYSTAL induced robust tumor regression in advanced murine and rabbit models, remodeled immunosuppressive environments, and promoted host STING–dependent CD8+ T cell priming. CRYSTAL activated interferon responses in human head and neck squamous cell carcinoma biopsies, underscoring its translational potential for cancer immunotherapy.

“Because our immune system is designed to protect against pathogens, we believe we can utilize our immune system to fight against many other diseases, including cancer. So my lab has been using drugs, as well as dietary fibers that can boost immune responses against various diseases, including cancer.”

Congratulations, Dr. Carlos Aguilar, on being named to the College of Fellows of the American Institute for Medical and Biological Engineering (AIMBE). Election to the AIMBE College of Fellows is among the highest professional distinctions accorded to medical and biological engineers, comprised of the top two percent of engineers in these fields.

New Exciting Paper from BI Core Faculty, Dr. Jae-Won Shin.

“We present an integrated platform that combines parallel deterministic single-cell encapsulation acrossmultiple microgel sizes with machine-learning analysis of cell morphology, revealing size-dependentphenotypes and enabling prediction of microenvironmental confinement.”