Nanotechnology
Nanostructured materials represent the one of the five technological pillars of the Biointerfaces Institute. The focus of this work is on simulating nanomaterial self-assembly and developing the different kinds of nanotubes, nanoprobes, nanocatalysts and nanostructures for applications in medicine, energy conversion, and electronics.
Biointerfaces Institute researchers use nanostructured materials in drug delivery, neural interface, rare cell detection, different imaging modalities, and microfluidics organ replicas. Research groups from UM Medical School or Biomedical Engineering department focusing on the end-use therapeutics or diagnostics utilize nanoparticles developed by BI research groups specializing in particle synthesis. Some of the nanomaterials that developed in BI are unique to UM. They include “janus” biodegradable nanoparticles, iron sulfide (FeS2) nanoparticles, aramid nanofibers (ANFs), and biomimetic composites. Examples of ongoing projects taking advantage of unique properties of nanomaterials developed at the Biointerface Institute include selective targeting of breast cancer cells, long-term implants for brain recording, artificial bone marrow, single cell metabolism monitoring with SERS-active nanoparticle assemblies, and others.
Basic research on nanomaterials that is expected to advance the field of biointerfaces in the next 5-10 years includes replication of protein functions by inorganic nanostructures, theory and practice of nanoparticle self-organization phenomena, DNA mechanics, high-speed computer simulations of nanoparticle dynamics, membrane-particle interactions, and wetting at nanoscale interfaces. Considerable effort is also invested in understanding the challenges for scaled up manufacturing nanoscale materials and devices by bridging nanotechnologies with different types of high-throughput lithography and microelectromechanical devices.
Surface Corrugation offers important parameters to design physico-chemical properties of particles. The 'Hedgehog' particles are constructed by hydrothermal and sonochemical growth of ZnO nanowires on arbitrary microspheres.
The micron scale ovals, constructed by self-assembly of CdTe nanoparticles, are buried under layers of graphene oxide sheets. This image depicts a handful of buried eggs ready to hatch.
Related Press Releases & Articles
- April 16, 2018 / YouTube Video
Tuteja lab reports on new omniphobic coatings that repel almost everything
In a paper recently published in ACS Applied Materials & Interfaces, the Tuteja lab reports on recent findings on omniphobic coatings that could be applied on a variety of surfaces to repel almost any liquid.
- April 11, 2018 / Award
Kotov awarded Vannevar Bush Faculty Fellowship
Nick Kotov is one of members of the 2018 class of the Vannevar Bush Faculty Fellowship, awarded by the Department of Defense.
- March 1, 2018 / Article
Interdisciplinary team of BI researchers publish new article on 3-D Jet Writing Technique
The article entitled “3D Jet Writing: Functional Microtissues Based on Tessellated Scaffold Architectures” appears in Advanced Materials.
- February 22 @ 2:00 pm
Seminar on “Materials for Biodegradable Electronics” – John Rogers, Northwestern University
This event is co-hosted by the University of Michigan ACS POLY/PMSE Student Chapter and the Biointerfaces Institute Researcher Group.
- February 21, 2018 / YouTube Video
Kotov awarded Gold Prize Award in the Mobile World Scholar Challenge
Nick Kotov’s work on biomimetic composites is recognized by the Mobile World Scholar Challenge
- January 25, 2018 / Featured
New Science Article from the Kotov Lab
The article entitled “Chiromagnetic Nanoparticles and Gels” appeared in the January 19 issue of Science.
- January 23, 2018 / Press Release
Diabetes and Its Complications Challenge Seed Funds Awards
We are pleased to announce our selection for the Diabetes and Its Complications Challenge seed fund competition.
- November 29, 2017 / Press Release
Nanoparticles self-assemble into nanoshells
Research in the Kotov group demonstrated the self-assembly of inorganic nanoparticles into nanoshells, which can potentially be used for gene delivery applications. More details here.
- November 29, 2017 / Featured
Kevlar-Based Cartilage
Nick Kotov develops artificial cartilage materials from Kevlar-based nanofibers.
- November 5, 2017 / Press Release
Lee Lab – Bioplasmonics Group
The Bioplasmonics Group, directed by Prof. Somin Lee, works at the interface between life science, physical science and engineering, drawing from a combination of bottom-up and top-down nanofabrication approaches, to design and develop smart biophotonic technologies and uncover biological complexities in the development of tissues and in cancer. Specifically, they have recently developed novel tools, including an mechano-optical plasmonic nanoantenna, to measure the temperature of proteins in cells. Prof. Lee received a Young Investigator Award from the Air Force Office of Scientific Research (AFOSR) to support this research.
- October 24, 2017 / Article
Glotzer article in Langmuir
The Glotzer group published an article entitled “Virial Coefficients and Equations of State for Hard Polyhedron Fluids” in Langmuir.
- October 18, 2017 / Featured
Langmuir cover highlights research from Larson and Solomon
Research on controlled levitation of surface-modified colloids by electric fields was recently published in Langmuir and selected as the issue’s cover art. The work was performed in Ron Larson and Michael Solomon’s groups. Lead author, Carlos A. Silvera Batista, was a UM Presidential Postdoctoral Fellow in the Solomon lab and recently joined the Department of Chemical Engineering at Vanderbilt University as an Assistant Professor.
- October 16, 2017 / Article
The Kotov group reports on stretchable conductors
The article “Stretchable conductors by kirigami patterning of aramid-silver nanocomposites with zero conductance gradient” appeared in Applied Physics Letters.
- October 11, 2017 / Article
An article co-authored by Green, Larson and Solomon published in Physical Review Letters
Joint research in the Green, Larson and Solomon groups published in Physical Review Letters in an article entitled “Rheological State Diagrams for Rough Colloids in Shear Flow”.
- October 2, 2017 / Article
The Larson group reports on new computational models to study interactions within solid dispersion formulations
Their research findings appeared in Molecular Pharmaceutics in an article entitled “Multiscale Computational Modeling of the Nanostructure of Solid Dispersions of Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS) and Phenytion”.
- September 18, 2017 / Article
Report on the role of branched nanofibers in 3-dimensional networks
An article co-authored by N. Kotov and P. Green reports on the role of branched aramid nanofibers in three-dimensional network. The article appeared in Angewandte Chemie.
- August 14, 2017 / Press Release
Mike Solomon appointed Interim Dean of Rackham
Mike Solomon has been appointed as interim dean and interim provost for academic affairs-graduate studies of the UM Rackham Graduate School.
For more info on this appointment, please visit here.
- July 31, 2017 / Press Release
New technique from Kim and team leads to heat-conducting plastic
Along with Kevin Pipe, research performed by Jinsang Kim’s group regarding a process to change plastic’s molecular structure to better dissipate heat was published in the July issue of Science Advances.
- July 5, 2017 / Article
The Shea group investigates antigen-conjugated nanoparticle treatment
The article entitled “Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression of T Cell Activity to Induce Tolerance” was published in Molecular Therapy.
- June 1, 2017 / Article
Solomon and VanEpps report on biofilms
Effect of Antimicrobial and Physical Treatments on Growth of Multispecies Staphylococcal Biofilms
Our Nanotechnology Researchers
Advanced Materials and Drug Delivery
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Ron Larson
A. H. White Distinguished University Professor of Chemical Engineering; George Granger Brown Professor of Chemical Engineering; Professor: Mechanical Engineering and Macromolecular Science and Engineering Research Focus: Nanotechnology Contact Information:rlarson@umich.eduThe Larson Group’s research interests include the structure and flow properties of viscous or elastic fluids, sometimes called “complex fluids,” which include polymers, colloids, surfactant-containing fluids, liquid crystals, and biological macromolecules such as DNA, proteins, and lipid membranes. The Larson group applies these concepts to drug release materials, coating materials, personal care products, and other applications of advanced materials.
Sharon Glotzer
Anthony C. Lembke Department Chair of Chemical Engineering; John Werner Cahn Distinguished University Professor of Engineering; Stuart W. Churchill Collegiate Professor of Chemical Engineering; Professor: Materials Science and Engineering, Macromolecular Science and Engineering, Physics, and Applied Physics Research Focus: Nanotechnology Contact Information:sglotzer@umich.eduGlotzer’s research on computational assembly science and engineering aims toward predictive materials design of colloidal and soft matter, with current emphasis on shape, packing, and assembly pathways.
Peter Tessier
Albert M. Mattocks Professor of Pharmaceutical Sciences and Chemical Engineering Research Focus: Advanced Materials and Drug Delivery, Nanotechnology Contact Information:ptessier@umich.eduThe Tessier lab aims to develop next generation technologies for designing, discovering, engineering, characterizing, formulating and delivering biologics ranging from small affinity peptides to large monoclonal antibodies for molecular imaging, diagnostic and therapeutic applications.
Nicholas Kotov
Joseph B. and Florence V. Cejka Professor of Engineering; Professor: Chemical Engineering, Materials Science and Engineering, Biomedical Engineering, and Macromolecular Science and Engineering Research Focus: Nanotechnology, Single Cell Technologies Contact Information:kotov@umich.eduResearch in the Kotov Group focuses on self-organization of nanocolloids, layer-by-layer assembly, ultrastrong nanocomposites, tissue engineering with nanomaterials, nanoscale drugs, and implantable biomedical devices.
Peter Green
Professor Materials Science and Engineering, Chemical Engineering, and Macromolecular Science and Engineering Research Focus: Nanotechnology Contact Information:pfgreen@umich.eduResearch in the Green Group is devoted to developing a fundamental understanding of, and controlling, the structure and properties of “soft” materials for applications that include: energy conversion, active and passive coatings, membranes, sensors and organic electronic, and electrorheology.
Somin Eunice Lee
Assistant Professor Electrical Engineering and Computer Science, Biomedical Engineering, and Macromolecular Science and Engineering Research Focus: Nanotechnology Contact Information:sleee@umich.eduDr. Lee and the Bioplasmonics Group focuses on advancing innovations utilizing nanoscale-dependent properties to enable unique spatial and temporal capabilities needed for quantification in bioscience and medicine. Areas of expertise include plasmonics, nanophotonics, and bionanotechnologies.
Michael Solomon
Professor: Chemical Engineering, Macromolecular Science and Engineering; Interim Dean: Rackham School of Graduate Studies Research Focus: Nanotechnology Contact Information:mjsolo@umich.eduThe Solomon Group research interests are in the area of soft matter – materials with properties intermediate between fluids and solids. The Solomon group has developed and applied 3D confocal microscopy, rheological, and light scattering methods to study the soft matter phenomena of self-assembly, gelation, and the biomechanics of bacterial biofilms.
Anna Schwendeman
Assistant Professor Pharmaceutical Sciences Research Focus: Nanotechnology Contact Information:annaschw@umich.eduSchwendeman’s principal research interest is to understand how phospholipid composition of high-density lipoprotein (HDL) affects its potency and to design short synthetic peptides that mimic various functions of Apolipoprotein A-I, the main HDL protein. Laboratory work focuses on HDL for treatment of sepsis, Alzheimer’s disease, complications of diabetes, lupus and other autoimmune diseases and using synthetic HDL nanoparticles for targeted drug delivery purposes and designing artificial HDL based on gold nanoparticles.