Machine learning-driven single-cell phenotyping in size-controlled microenvironments via parallel deterministic droplet microfluidics
March 20, 2026New Exciting Paper from BI Core Faculty, Dr. Jae-Won Shin.
“We present an integrated platform that combines parallel deterministic single-cell encapsulation acrossmultiple microgel sizes with machine-learning analysis of cell morphology, revealing size-dependentphenotypes and enabling prediction of microenvironmental confinement.”
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Michigan Research – December 2025: From Discovery to Real-World Impact
December 18, 2025The December 2025 Michigan Research newsletter highlights how U-M researchers are turning bold ideas into real-world solutions. Featured work includes Cindy Chestek’s groundbreaking research on thought-controlled prosthetics, alongside advances in AI-enabled healthcare, interdisciplinary science, and innovation that directly improves lives.
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A Blood Test That Shows If Brain Cancer Treatment Is Working
December 16, 2025“There are tiny particles floating in patient blood, called extracellular vesicles, that have been released by the cancer cells. The big challenge is figuring out how to find and pull out only those that come from cancer cells and not from elsewhere in the body,” – Dr. Sunitha Nagrath
Dr. Sunitha Nagrath Appointed Dwight F. Benton Professor of Chemical Engineering
December 11, 2025We are thrilled to announce that Dr. Sunitha Nagrath has been named the Dwight F. Benton Professor of Chemical Engineering!
In celebration of Dr. Nagrath’s innovative leadership in microfluidics and cancer diagnostics, and her dedication to translating engineering breakthroughs into tools that improve patient care. Her lab’s “smart chips” can isolate and analyze rare circulating tumor cells. A major stride in cancer research and diagnostics.
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Researchers Shine New Light on the Complex Nature of Rituximab
December 10, 2025A new study just revealed not all batches of Rituximab (Rituxan®) are created equal. These findings highlight how critical rigorous quality control and careful characterization are for biologic medicines
Twenty-Nine U-M College of Pharmacy Faculty Among the World’s Top 2% of Scientists
December 3, 2025Congratulations to Dr. James Moon, Dr. Steven Schwendeman, Dr. Anna Schwendeman, Dr. Guizhi (Julian) Zhu, and Dr. Peter Tessier on being named as apart of 2025’s World’s Top 2% Scientists Network!
Their continued impact on the scientific community is inspiring!
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Digital-Twin Models Bring Patient-Level Metabolic Flux Analysis to Brain Cancer
December 1, 2025A new study by the Deepak Nagrath lab unveils two machine-learning, powered frameworks that estimate metabolic fluxes directly in brain-cancer patients, a major advance over prior studies limited to preclinical models.
Hijacking the Brain’s Highways for Better Therapies
November 20, 2025“We want to inject large molecules — proteins, peptides, nucleic acids — into the bloodstream and have them cross the blood-brain barrier in an efficient and predictable way to get them into the brain interior,” – Dr. Peter Tessier
A New Era for Bone Health Begins, Dr. Greineder’s Latest Venture
November 17, 2025Skeletalis is now live, driven by Colin Greineder and his fellow cofounders’ pioneering work in bone-targeted therapeutics.
Osteoporosis affects over 10 million adults in the U.S., yet current treatments still fall short. Their team is rethinking how osteoporosis drugs interact with bone, aiming for safer, more durable therapies that truly meet patient needs.
This is the future of skeletal health, and they’re building it now.
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U-M Awards New Commercialization Fellowships: Including Shea Lab Innovator
November 14, 2025Among the awardees is Brian Ross (PI: Lonnie Shea lab), whose work on advanced cell-capture scaffolding is advancing toward real-world impact under the startup Porosity Bio.
Expanding Mind & Matter: Turning Brain Tumors into Manageable Conditions
November 11, 2025“When the tumor progresses 10 years later, there are no treatments. That’s what this grant is about: to develop treatment for when this disease comes back and becomes deadly… In this grant we will investigate how these immune cells are modified, how the tumor cells talk to the bone marrow, and how these reprogrammed immune cells go back into the brain microenvironment to modify the immune response against the tumor,” – Dr. Maria Castro
Turning Health Research Inside Out: Collaboration as the Catalyst for Discovery
November 3, 2025“The Institute comes at research from the opposite direction—we start by asking “what’s the big problem we want to solve?” And by starting with the big picture, we can identify all the different domains that need to be involved and enable them to work together as a team from the outset,” – Dr. Joerg Lahann
Advancement in Noninvasive Blood Test to Guide Breast Cancer Treatment Decisions
October 29, 2025A groundbreaking study led by Dr. Sunitha Nagrath and Dr. Max Wicha is bringing precision medicine one step closer to reality. Their team has developed an innovative “labyrinth” microfluidic chip that can capture circulating tumor cells (CTCs) from a simple blood sample. By isolating and analyzing cancer cells directly from the bloodstream, the research opens the door to noninvasive, real-time insights into tumor biology and treatment response. It’s a major leap toward personalized cancer care.
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AI Meets Single-Cell Biology: Next-Gen Biomedical Models
October 23, 2025Researchers are exploring how large language models (LLMs) can revolutionize single-cell biology. Their new paper highlights how “single-cell LLMs” could accelerate discovery in genomics, disease modeling, and personalized medicine. The team also calls for open collaboration, standardized datasets, and transparency to make AI-driven biology more reliable and accessible.
BI Research Week Recap
October 23, 2025The Biointerfaces Institute hosted our first ever Research Week! An expansion of our previously established Research Day, BI hosted a plethora of events expressive of our institutions dedication to innovative science!
We give our appreciation to those who participated in our events, and we are glad so many were able to join us!
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